Investigation of the Differences Between the Different Angiogenic and Antiangiogenic Markers Before and After Treatment in Several Types of Cancer

Authors

  • Funda KOSOVA Department of Medical Biochemistry, Manisa Celal Bayar University, Vocational School of Health Sciences, Manisa, Turkey.
  • Özgü Kemal BEKSAÇ Department of Medical Biochemistry, Manisa Celal Bayar University, Medical Faculty, Manisa, Turkey
  • Bahadır ÇETİN Department of General Surgery, Ankara Oncology Hospital, Ankara, Turkey

Keywords:

Cancer, NF-kB, VEGF, MMP-9, Endostatin ve Trompospondin -1

Abstract

Cancer is among the most common deaths in the world, and there are many studies on the increased invasion with angiogenesis. In this study, we aimed to compare angiogenic and antiangiogenic markers in various cancer patients before and after surgery in order to explain the mechanism of angiogenesis in more detail. Methods: Our study consists of 20 controls and 20 cases (before and after surgery). After all the blood was collected, our samples were stored at -80 ° C until the analysis period and the samples were analyzed by ELISA method. Results: There was no significant difference in age, gender and weight of these groups (p>0.05). When the control group was compared with the pre-op group, we observed that the levels of TSP-1, ES, NF-?B in the pre-op group were high in each of the various types of cancer, while VEGF was low in all except in the breast. MMP-9 was found to be high in all cancer types. When pre-op and post-op were compared, there was an increase in TSP, ES, NF-?B, VEGF and MMP-9 levels in the colon and thyroid, while there was no statistically increase in the others (p <0.05). Conclusion: In our study, we think that all markers are high in the preop period in all types of cancer, and that there is a statistical increase in the postop period, this is related to the duration of the treatment. We anticipate that this study should be performed by applying more cases and longer treatment.

Published

2020-07-31

How to Cite

KOSOVA, F. ., BEKSAÇ, Özgü K. ., & ÇETİN, B. (2020). Investigation of the Differences Between the Different Angiogenic and Antiangiogenic Markers Before and After Treatment in Several Types of Cancer . Journal of Medical Reviews, 3(07), 4-12. Retrieved from http://medicalreviews.info/index.php/jmr/article/view/88

Issue

Section

Articles